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FLASH GENE

Symbol

P53AIP1

contributors: mct/npt - updated : 19/09/2008

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11q24      Physical location : -
Genatlas name	p53-regulated apoptosis-inducing protein 1
Synonym symbol(s)	TP53AIP1

DNA

TYPE	functioning gene
STRUCTURE	7.00 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant alpha - splicing 806 12 124 - Oda variant beta - splicing 777 8 86 - Oda variant gamma 2 splicing 2659 11 108 - Oda, Sawaya (2008)

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth tongue     predominantly Nervous brain       moderately Reproductive female system ovary     moderately Respiratory lung       lowly Skin/Tegument skin       moderately Urinary bladder       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

HOMOLOGY

Homologene

FAMILY

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria

basic FUNCTION	mediating p53-dependent apoptosis
	pivotal mediator of the p53-dependent mitochondrial apoptotic pathway

CELLULAR PROCESS	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

induced by

p53

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   may play a role in gastric carcinogenesis in patients infected with H. pylori infection

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS