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FLASH GENE
Symbol P2RY11 contributors: mct - updated : 27-08-2011
HGNC name purinergic receptor P2Y, G-protein coupled, 11
HGNC id 8540
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
Homologene
FAMILY
  • G-protein coupled receptor 1 family
    • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    text integral to plasma membrane
    basic FUNCTION
  • acting as a receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems
  • acting as a purinergic nucleotide receptor, G-protein coupled
  • acting as a rhodopsin-like receptor
  • endogenous receptor in granulocytes mediating the sustained [Ca2+] increase responsible for their functional activation
  • implicated in inhibition of neutrophil apoptosis by ATP
  • highly expressed in CD8+ T cells and natural killer cells and modulates immune cell viability
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • ADP
    • protein
    cell & other
    REGULATION
    induced by DMSO
    retinoic acid
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to narcolepsy
    Variant & Polymorphism SNP rs2305795 associated with narcolepsy
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinfectious 
    potential target for pharmacologic intervention aimed at reducing NK-mediated vascular injury
    ANIMAL & CELL MODELS