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FLASH GENE

Symbol

P2RY11

contributors: mct - updated : 27-08-2011

HGNC name	purinergic receptor P2Y, G-protein coupled, 11
HGNC id	8540

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	3.87 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002566 2 - 1977 - 374 - 2001 11278528

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel       highly Endocrine pancreas       highly Homo sapiens Reproductive female system uterus cervix   predominantly Skin/Tegument skin       highly Visual eye       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Connective bone

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic neutrophil Homo sapiens Endocrine islet cell (alpha,beta...) Homo sapiens Lymphoid/Immune natural killer Homo sapiens Lymphoid/Immune T cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY

G-protein coupled receptor 1 family

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION	plasma membrane
text	integral to plasma membrane

basic FUNCTION	acting as a receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems
	acting as a purinergic nucleotide receptor, G-protein coupled
	acting as a rhodopsin-like receptor
	endogenous receptor in granulocytes mediating the sustained [Ca2+] increase responsible for their functional activation
	implicated in inhibition of neutrophil apoptosis by ATP
	highly expressed in CD8+ T cells and natural killer cells and modulates immune cell viability

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATP
	ADP

protein

cell & other

REGULATION

induced by	DMSO
		retinoic acid

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to narcolepsy

Variant & Polymorphism SNP	rs2305795 associated with narcolepsy

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed immunology infectious   potential target for pharmacologic intervention aimed at reducing NK-mediated vascular injury

ANIMAL & CELL MODELS