Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

USP6

contributors: mct/pgu - updated : 09-02-2015

HGNC name	ubiquitin specific protease 6 (Tre-2 oncogene)
HGNC id	12629

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   translocation     translocated at high frequency in aneurysmal bone cyst (ABC), a pediatric osseous neoplasm tumoral fusion       t(16;17)(q22;p13) the most frequent chromosomal aberration with translocation generating a CDH11-USP6 fusion gene in aneurysmal bone cyst tumoral   translocation     t(17;17) resulting in a COL1A1-USP6 chimeric gene in aneurysmal bone cyst tumoral     --over   attenuated osteoblast maturation caused by USP6 overexpression may contribute to the bone loss/destruction observed in aneurysmal bone cyst tumoral fusion       rearrangements of both USP6 and SS18, but histologic features were consistent with aneurysmal bone cyst throughout the lesion

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS