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FLASH GENE
Symbol JSRP1 contributors: mlc/npt - updated : 11-01-2008
HGNC name junctional sarcoplasmic reticulum protein 1
HGNC id 24963
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a cytoplasmic domain
  • a single transmembrane segment
  • an intralumenal domain enriched in positively charged amino acids
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    text skeletal muscle sarcoplasmic reticulum
    basic FUNCTION
  • intracellular membrane compartment controling intracellular calcium concentration and therefore playing a role in excitation-contraction coupling
  • involved in the molecular mechanism underlying skeletal muscle excitation-contraction coupling
  • involved in the development or maintenance of skeletal muscle strength
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with the alpha1.1 subunit voltage-gated calcium channel and calsequestrin
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS