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FLASH GENE
Symbol PKD1L3 contributors: mct - updated : 08-09-2020
HGNC name polycystic kidney disease 1-like 3
HGNC id 21716
Location 16q22.2      Physical location : 71.963.441 - 72.033.877
Synonym name
  • PC1-like 3 protein
  • DNA
    TYPE functioning gene
    STRUCTURE 70.84 kb     30 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    30 - 5199 - 1732 - 2010 20538909
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon lowly
     liver   lowly
    Gustatory (taste)     
    Visualeye   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • eleven transmembrane domains
  • a latrophilin/CL-1-like GPCR proteolytic site (GPS) domain
  • a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain
  • an N-terminal C-type lectin domain
  • a central GPCR proteolytic site
  • a pair of PKD domains
  • a C-terminal putative channel pore region
  • HOMOLOGY
    interspecies ortholog to murine Pkd1l3
    Homologene
    FAMILY
  • polycystin protein family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text integral to membrane
    basic FUNCTION
  • involved in cation transport
  • transient receptor potential (TRP) channel members
  • may function as sour taste receptor
  • brush cells may be able to sense a local acidification , and they express the channel PKD1L3 which contributes to the acid responsiveness of gustatory sensory cells
  • PKD2L1 and PKD2L1/PKD1L3 channels share the PKD2L1 trimerization process
  • influx-operated Ca(2+) entry via PKD2L1 and PKD1L3 Channels facilitates sensory responses to polymodal transient stimuli
  • PKD2L1 take part in hedgehog signaling in renal primary cilia and sour tasting coupling with PKD1L3
  • PKD1L3 associates with PKD2L1 in taste cells and may play a role in sour taste
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text
  • cation transport
  • PATHWAY
    metabolism
    signaling neurotransmission
  • neuropeptide signaling pathway
  • a component part of PKD1L3/PKD2L1 channel (a new type of ion channel, designated as an off-channel; activation of PKD1L3/PKD2L1 channels might occur shortly after acid stimulation, as a slight increase in pH from the initial acidification at pH 2.5 is sufficient to open the channels)
    INTERACTION
    DNA
    RNA
    small molecule metal binding, other,
  • Ca2+
  • sugar
  • protein
  • PKD1L3, is a protein that associates with PKD1L2 in taste cells and may play a role in sour taste
  • cell & other
    REGULATION
    activated by by various acids when coexpressed in heterologous cells but not by other classes of tastants
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS