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FLASH GENE
Symbol PCYT2 contributors: mct - updated : 23-11-2021
HGNC name phosphate cytidylyltransferase 2, ethanolamine
HGNC id 8756
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to rattus Pcyt2
ortholog to murine Pcyt2
ortholog to drosophila Pect
Homologene
FAMILY cytidylyltransferase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
basic FUNCTION
  • catalyzing the formation of CDP-ethanolamine from ethanolamine
  • important regulatory enzyme in phosphatidylethanolamine and plasmalogen biosynthesis
  • PCYT2 is the main regulatory enzyme in de novo biosynthesis of PE from ethanolamine and diacylglycerol by the CDP-ethanolamine Kennedy pathway
  • plays a pivotal role in the execution of the processes deregulation of which could lead to the development of obesity, insulin resistance, liver steatosis and dyslipidemia
  • PCYT2 and membrane Phosphatidylethanolamine (PE) biogenesis as important determinants of gender-specific differences in cardiac lipids and heart function
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
  • second step of phospholipid biosynthesis and CDP-ethanolamine synthesis
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NFYA, NFYB, NFYC and YY1 are important for the basal transcription of PCYT2 and NFY is involved in the inhibitory effects of 25-HC on PCYT2 transcription
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPG82
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    reduced phosphoethanolamine (PEtn)levels and tumor growth
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS