basic FUNCTION
| implicated in ubiquitin E3 ligase complex that enhances cellular survival following DNA damage |
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zinc-dependent metalloproteases, that possesses DUB activity specifically for K63-Ub polyubiquitin chains |
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plays an important role in recruiting BRCA1 to DNA damage sites, as BRCC3 deficiency leads to decreased BRCA1 accumulation at DNA damage sites |
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regulates the abundance of Lys(63)-linked ubiquitin chains at chromatin |
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critical interactions required for the formation and function of BRCC3-containing DUB complexes |
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is a critical factor involved in TERF2-dependent telomere protection suggesting that an important physiological function of the BRCA1 complex is to maintain genomic stability aiding telomere associated proteins in maintaining telomere integrity |
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is an important regulator of the mitotic spindle assembly and cell division |