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FLASH GENE
Symbol ZNF593 contributors: - updated : 02-09-2005
HGNC name zinc finger protein 593
HGNC id 30943
Location 1p36.11      Physical location : 26.496.387 - 26.497.362
Synonym symbol(s) ZT86
DNA
TYPE functioning gene
STRUCTURE 0.00 kb     3 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Lymphoid/Immunelymph node   highly
 spleen   predominantly
Nervousbrain   highly
Reproductivefemale systemplacenta  highly
Urinarybladder   moderately
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a C2H2-type zinc finger
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • negatively modulating the DNA binding activity of POU2F2 and therefore its transcriptional regulatory activity
  • could act either by binding to DNA octamer or by interacting with POU2F2
  • may also be a modulator of other octamer-binding proteins
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • POU2F2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS