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FLASH GENE
Symbol WFIKKN2 contributors: mct - updated : 30-04-2014
HGNC name WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
HGNC id 30916
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a WAP domain
  • many conserved domains associated with protease-inhibitory proteins, including a whey acidic protein domain
  • a follistatin/Kazal domain
  • an Ig domain
  • two tandem Kunitz domains
  • a netrin domain
    • HOMOLOGY
    interspecies ortholog to murine Wfikkn2
    intraspecies paralog to WFIKKN1
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • may control the action of multiple types of proteases
  • in brain may be regulating the action of GDF11
  • both WFIKKN2 and WFIKKN1 act by blocking the initial binding of the ligand to its receptor
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds mature MSTN/myostatin and myostatin propeptide and inhibits the biological activity of myostatin
  • with WFIKKN1, also binds to GDF11
  • WFIKKN1 and WFIKKN2 proteins are antagonists of MSTN and GDF11, but in the case of TGFB1, BMP2 and BMP4 they function as growth factor binding proteins
  • both WFIKKN1 and WFIKKN2 bind MSTN and GDF11 (growth and differentiation factor 11) with high affinity and are potent antagonists of these growth factors
  • interactions with MSTN and GDF11 are mediated primarily by the follistatin and NTR domains
  • WFIKKN1 may have greater potential as an antimyostatic agent than WFIKKN2
  • WFIKKN1 and WFIKKN2 are important modulators of GDF11 and MSTN activity
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS