| Symbol
| ID1
| contributors: mct/pgu - updated : 15-12-2015
|
| HGNC name
| inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
|
| HGNC id
| 5360
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
| --low
|
| |
in gastric cancer | | tumoral
|
|
| --over
|
|
in prostate cancer tissues  | | tumoral
|
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|
|
| |
expression in androgen-dependent prostate cancer is negatively regulated by androgen through androgen-receptor | | tumoral
|
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| |
expression of mRNA in bone marrow and peripheral blood was significantly associated with lymph node metastasis and peritoneal dissemination in gastric carcinoma patients | |
Variant & Polymorphism
| 
| |
| Candidate gene
| plays an important role in polycythemia vera |
Marker
| Therapy target
| | |
|
| System | Type | Disorder | Pubmed |
|---|
| cancer | urinary | | |
| upregulation of ID1 in bladder cancer cells lead to increased cell viability in response to epirubicin and downregulation of Id1 increases cellular sensitivity to epirubicin by increased anticancer drug-induced apoptosis | | cancer | reproductive | breast | |
| peptide aptamer, Id1/3-PA7, specifically interacting with ID1 and ID3, could represent a nontoxic exogenous agent that can significantly provoke antiproliferative and apoptotic effects in breast cancer cells, which are associated with deregulated expressi |
| |
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| combined Id1 and Id3 deletion leads to dysregulation of the hematopoietic transcriptional network and multiple defects in erythropoietic development in adult mice |