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FLASH GENE
Symbol ID1 contributors: mct/pgu - updated : 15-12-2015
HGNC name inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
HGNC id 5360
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
in gastric cancer
tumoral     --over  
in prostate cancer tissues
tumoral        
expression in androgen-dependent prostate cancer is negatively regulated by androgen through androgen-receptor
tumoral        
expression of mRNA in bone marrow and peripheral blood was significantly associated with lymph node metastasis and peritoneal dissemination in gastric carcinoma patients
Susceptibility
Variant & Polymorphism
Candidate gene
  • plays an important role in polycythemia vera
  • Marker
    Therapy target
  • SystemTypeDisorderPubmed
    cancerurinary 
    upregulation of ID1 in bladder cancer cells lead to increased cell viability in response to epirubicin and downregulation of Id1 increases cellular sensitivity to epirubicin by increased anticancer drug-induced apoptosis
    cancerreproductivebreast
    peptide aptamer, Id1/3-PA7, specifically interacting with ID1 and ID3, could represent a nontoxic exogenous agent that can significantly provoke antiproliferative and apoptotic effects in breast cancer cells, which are associated with deregulated expressi
    ANIMAL & CELL MODELS
  • combined Id1 and Id3 deletion leads to dysregulation of the hematopoietic transcriptional network and multiple defects in erythropoietic development in adult mice