basic FUNCTION
| transcriptional repressor of CDKN2A |
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inhibiting transcription factors of the basic helix loop helix family |
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acting as inhibitors of the basic helix-loop-helix (bHLH) transcription factors that control cell differentiation, development and carcinogenesis |
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controlling growth and/or differentiation of several cell types (negatively) |
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potentially required for neurogenesis and angiogenesis (inducing inactivation of p16 (INK4a)/pRB pathway |
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involved in TGF beta 1 signaling pathway in active heterodimers with the b HLH transcription factors through their HLH motifs |
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required for the mobilization of endothelial precursor cells from the bone marrow during pathological tumor angiogenesis, and its expression remains high in tumor neovasculature |
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having tumor-initiating capacity to rare breast cancer cells within the more common types of breast tumors with high lung metastatic potential |
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play an essential role in the regulation of breast epithelial cell differentiation and proliferation |
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attenuates Notch signaling and impairs T-cell commitment by elevating DTX1 expression |
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promotes expansion and survival of primary erythroid cells and is a target of JAK2V617F-STAT5 signaling |
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inhibiting breast cancer cell grotwh through the upregulation of p21 gene expression via the interaction with ERBeta1 |
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ID1 and ID3 negatively regulate the transition from lineage-specified hemogenic cells to committed hematopoietic progenitors during hematopoiesis of both embryonic stem cells and induced pluripotent stem cell |