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FLASH GENE
Symbol ID1 contributors: mct/pgu - updated : 15-12-2015
HGNC name inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
HGNC id 5360
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus   highly
Cardiovascularheart   highly
Digestiveliver   lowly
Endocrinepancreas   highly
Nervousbrain   highly
Reproductivemale systemprostate  highly
Respiratorylung   highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Connective    
Epithelialsecretoryglandularendocrine 
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
 digestive
Lymphoid/ImmuneB cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, pregnancy
cell cycle     cell cycle, interphase, G1
Text during early development, in progenitor cells, and specifically detected in the epithelial cells of growing ductal structures during early pregnancy
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
  • basic helix-loop-helix (bHLH) domain
  • conjugated ubiquitinated
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Id1 (94.6pc)
    homolog to rattus Id1 (92.6pc)
    Homologene
    FAMILY
  • helix loop helix family of proteins
  • ID subfamily
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • transcriptional repressor of CDKN2A
  • inhibiting transcription factors of the basic helix loop helix family
  • acting as inhibitors of the basic helix-loop-helix (bHLH) transcription factors that control cell differentiation, development and carcinogenesis
  • controlling growth and/or differentiation of several cell types (negatively)
  • potentially required for neurogenesis and angiogenesis (inducing inactivation of p16 (INK4a)/pRB pathway
  • involved in TGF beta 1 signaling pathway in active heterodimers with the b HLH transcription factors through their HLH motifs
  • required for the mobilization of endothelial precursor cells from the bone marrow during pathological tumor angiogenesis, and its expression remains high in tumor neovasculature
  • having tumor-initiating capacity to rare breast cancer cells within the more common types of breast tumors with high lung metastatic potential
  • play an essential role in the regulation of breast epithelial cell differentiation and proliferation
  • attenuates Notch signaling and impairs T-cell commitment by elevating DTX1 expression
  • promotes expansion and survival of primary erythroid cells and is a target of JAK2V617F-STAT5 signaling
  • inhibiting breast cancer cell grotwh through the upregulation of p21 gene expression via the interaction with ERBeta1
  • ID1 and ID3 negatively regulate the transition from lineage-specified hemogenic cells to committed hematopoietic progenitors during hematopoiesis of both embryonic stem cells and induced pluripotent stem cell
  • CELLULAR PROCESS cell life, differentiation
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text B-cell differentiation
    PATHWAY
    metabolism
    signaling signal transduction
    TGF beta 1 signaling pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting woth COPS5
  • interacting with ERbeta1
  • ARID3A is a binding partner for ID1 (shares structural similarities with ID1 and recently implicated in TGF-beta1 signaling during embryogenesis
  • NR1D1 could also mediate repression via ID1 binding in the absence of heme
  • regulated BMI1 transcription through MYC binding to its E-box in the promoter
  • link between ID1 and PcG proteins and ID1 may contribute potentially to tumor development through PcG-mediated epigenetic regulation
  • is a novel target of PRKCA signaling (PRKCA signaling regulates inhibitor of DNA binding 1 in the intestinal epithelium)
  • SMURF2 is an E3 ligase that ubiquitinates ID1 and ID3 (SMURF2-mediated ubiquitination and consequent degradation of ID1 or ID3 plays an important role in the regulation of Id expression in senescent cells
  • interaction with LARP6 (LARP6 may be an effective mediator of promoting endothelial proliferation, angiogenesis and wound healing probably by regulating VEGF together with ID1)
  • cell & other
    REGULATION
    induced by tumors in enfothelial progenitors cells
    TGFBeta1
    repressed by ZBTB18, repressing ID1, ID2, ID3, ID4 genes during corticogenesis
    Other downregulated as cells differentiate into pre-B and mature B cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in gastric cancer
    tumoral     --over  
    in prostate cancer tissues
    tumoral        
    expression in androgen-dependent prostate cancer is negatively regulated by androgen through androgen-receptor
    tumoral        
    expression of mRNA in bone marrow and peripheral blood was significantly associated with lymph node metastasis and peritoneal dissemination in gastric carcinoma patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • plays an important role in polycythemia vera
  • Marker
    Therapy target
  • SystemTypeDisorderPubmed
    cancerurinary 
    upregulation of ID1 in bladder cancer cells lead to increased cell viability in response to epirubicin and downregulation of Id1 increases cellular sensitivity to epirubicin by increased anticancer drug-induced apoptosis
    cancerreproductivebreast
    peptide aptamer, Id1/3-PA7, specifically interacting with ID1 and ID3, could represent a nontoxic exogenous agent that can significantly provoke antiproliferative and apoptotic effects in breast cancer cells, which are associated with deregulated expressi
    ANIMAL & CELL MODELS
  • combined Id1 and Id3 deletion leads to dysregulation of the hematopoietic transcriptional network and multiple defects in erythropoietic development in adult mice