Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | EIF2AK1 | contributors: mct/npt - updated : 28-12-2016 |
HGNC name | eukaryotic translation initiation factor 2-alpha kinase 1 |
HGNC id | 24921 |
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Corresponding disease |
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Location | 7p22.1 Physical location : 6.061.879 - 6.098.860 | ||
Synonym name | |||
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Synonym symbol(s) | HRI, KIAA1369, HCR | ||
EC.number | 2.7.1.37, 2.7.11.1 |
DNA |
TYPE | functioning gene |
SPECIAL FEATURE | overlapping, opposite orientation, tail to tail |
text | |
STRUCTURE | 36.98 kb 15 Exon(s) |
regulatory sequence | Binding site |
MAPPING | cloned | Y | linked | N | status | provisional |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | ubiquitous |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
organ(s) |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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conjugated | PhosphoP |
mono polymer | homomer , dimer , complex |
HOMOLOGY |
interspecies | ortholog to murine Eif2ak1 |
ortholog to rattus Eif2ak1 |
Homologene |
FAMILY | |
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CATEGORY | regulatory |
SUBCELLULAR LOCALIZATION | intracellular |
intracellular,cytoplasm |
CELLULAR PROCESS | protein, translation regulation |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling |
a component | |
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INTERACTION |
DNA |
RNA |
protein |
cell & other |
REGULATION |
activated by | binding of nitric oxide (NO) to the heme iron in the N-terminal heme-binding domain |
autophosphorylation |
induced by | cytochrome P450 inducers such as phenobarbital |
inhibited by | hemin by promoting the formation of a disulfide-linked | |
homodimer | ||
binding of carbon monoxide (CO) |
ASSOCIATED DISORDERS |
corresponding disease(s) | LEMSPAD |
Other morbid association(s) |
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Susceptibility |
Variant & Polymorphism
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Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |