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FLASH GENE
Symbol FRMD4A contributors: mct/npt - updated : 14-04-2010
HGNC name FERM domain containing 4A
HGNC id 25491
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a FERM domain
    • HOMOLOGY
    interspecies ortholog to murine Frmd4a
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    basic FUNCTION
  • regulator of epithelial polarity (Ikenouchi 2010)
  • controls the activation of ARF6 by connecting cytohesin family ARF6-specific GEFs and F2RL2 at primordial adherens junctions during epithelial polarization (Ikenouchi 2010)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of F2RL2/FRMD4A/CYTH1 complex that ensures accurate activation of ARF6, a central player in actin cytoskeleton dynamics and membrane trafficking, during junctional remodeling and epithelial polarization (Ikenouchi 2010)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS