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FLASH GENE
Symbol FRMD4A contributors: mct/npt - updated : 14-04-2010
HGNC name FERM domain containing 4A
HGNC id 25491
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  predominantly
Lymphoid/Immunespleen   highly
Respiratoryrespiratory tractlarynx  highly
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a FERM domain
    • HOMOLOGY
    interspecies ortholog to murine Frmd4a
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    basic FUNCTION
  • regulator of epithelial polarity (Ikenouchi 2010)
  • controls the activation of ARF6 by connecting cytohesin family ARF6-specific GEFs and F2RL2 at primordial adherens junctions during epithelial polarization (Ikenouchi 2010)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of F2RL2/FRMD4A/CYTH1 complex that ensures accurate activation of ARF6, a central player in actin cytoskeleton dynamics and membrane trafficking, during junctional remodeling and epithelial polarization (Ikenouchi 2010)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS