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FLASH GENE

Symbol

FRMD4A

contributors: mct/npt - updated : 14-04-2010

HGNC name	FERM domain containing 4A
HGNC id	25491

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	687.16 kb     25 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_018027 25 - 6804 NP_060497 - 1039 - Ikenouchi (2010)

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth tongue     predominantly Lymphoid/Immune spleen       highly Respiratory respiratory tract larynx     highly Urinary kidney       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous peripherous

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a FERM domain

HOMOLOGY

interspecies

ortholog to murine Frmd4a

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton
	intracellular,nucleus

basic FUNCTION	regulator of epithelial polarity (Ikenouchi 2010)
	controls the activation of ARF6 by connecting cytohesin family ARF6-specific GEFs and F2RL2 at primordial adherens junctions during epithelial polarization (Ikenouchi 2010)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

part of F2RL2/FRMD4A/CYTH1 complex that ensures accurate activation of ARF6, a central player in actin cytoskeleton dynamics and membrane trafficking, during junctional remodeling and epithelial polarization (Ikenouchi 2010)

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS