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FLASH GENE
Symbol SH3PXD2B contributors: mct/npt - updated : 10-11-2016
HGNC name SH3 and PX domains 2B
HGNC id 29242
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal phox homology (PX) domain
  • four Src homology 3 (SH3) domains, suggesting that it may be a novel scaffold protein (Iqbal 2010)
  • several proline-rich motifs
  • C-terminal SH3 domain (residues 853-911)
    • HOMOLOGY
    Homologene
    FAMILY
  • SH3PXD2 family
    • CATEGORY storage
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text predominantly localized to rosettes of podosomes (Buschman 2009)
    basic FUNCTION
  • plays a crucial role in the immediate early stage of adipogenesis (Iqbal 2010)
  • involved in the formation of actin-rich membrane protrusions called podosomes or invadopodia, which coordinate pericellular proteolysis with cell migration (Iqbal 2010)
  • implicated in MT1-MMP recruitment and ECM degradation (Buschman 2009)
  • podosomal-adaptor protein required for postnatal growth and development, particularly within physiologic contexts involving extracellular matrix regulation (Mao 2009)
  • SH3PXD2B, and SH3PXD2A are also required for proper embryonic development, probably because of their roles in cell migration
  • substrate of Src tyrosine kinase, implicated in the regulation of podosome formation
  • new function in the regulation of growth factor-dependent cell migration
  • is required for the formation of functional podosomes
  • scaffold protein that plays a role in podosome formation, EGFR signaling and ROS production
  • novel function in the regulation of mesenchymal stromal cells (MSCs) differentiation
  • importance of adaptor proteins SH3PXD2B, and SH3PXD2A in melanoma growth and metastasis, likely via functional invadopodia formation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • important component of podosomes likely to mediate protein-protein interactions with membrane-spanning metalloproteinases (Mao 2009)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SH3PXD2B, SH3PXD2A directly bind to NOXA1, and the integrity of the N-terminal PRR of NOXA1 is essential for this direct interaction with the Tks proteins
  • is a scaffold protein that plays a key role in regulating the actin cytoskeleton via SRC and CTTN
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) FTHS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS