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FLASH GENE

Symbol

ZNF395

contributors: mct - updated : 24-05-2011

HGNC name	zinc finger protein 395
HGNC id	18737

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	40.88 kb     10 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_018660 10 - 4807 - 513 - 2009 19018758

EXPRESSION

Type	ubiquitous

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive pancreas exocrine       moderately Lymphoid/Immune lymph node       highly   spleen       moderately   thymus       predominantly Reproductive female system placenta     moderately   male system testis     moderately Respiratory respiratory tract larynx     highly Urinary kidney       moderately Visual eye       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

two C-terminal four-amino acids motifs conserved to the so-called e-tail of certain T-cell factors)

HOMOLOGY

interspecies

homolog to murine Zfp395

Homologene

FAMILY

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus
text	shift from cytoplasm to nucleus by the treatment with an inhibitor of the nuclear export, leptomycin B, and mutagenesis of the putative nuclear export signals
	colocalization of ZNF395 and BAG6 in the nucleus might be an important factor for survival of osteosarcoma cells

basic FUNCTION	might play a role in transcription of PV genes and in E2-mediated repression
	transcription factors shuttling between nucleus and cytoplasm and binding to the specific GCCGGCG, which is an essential cis-element for HD gene expression in neuronal cells
	new cellular factor mediating the effects of PI3K/Akt signaling and 14-3-3 on cell growth
	nuclear-cytoplasmic shuttling factor with the ability to inhibit cell growth
	acts as a repressor of HPV (human papillomavirus) transcription (repression requires the DNA-binding activity of ZNF395, which we mapped to two C-terminal four-amino acids motifs conserved to the so-called e-tail of certain T-cell factors)
	ZNF395-mediated repression of transcription involves specific DNA-binding and the recruitment of the SIN3A-HDAC1 complex
	could induce apoptotic cell death via a caspase-9-independent pathway

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA	binding to the specific GCCGGCG

RNA

small molecule	metal binding,
	Zn2+

protein	binding to the unique promoter DNA sequences of the HD gene
	directly binds to SAP30 a component of the mSIN3A-HDAC1 complex, via AAs 263-312

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer bone   candidate target for immunotherapy in patients with osteosarcoma

ANIMAL & CELL MODELS