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FLASH GENE
Symbol ZNF395 contributors: mct - updated : 24-05-2011
HGNC name zinc finger protein 395
HGNC id 18737
Location 8p21.1      Physical location : 28.203.103 - 28.243.977
Synonym name
  • papillomavirus regulatory factor PRF-1
  • Huntington's disease gene regulatory region-binding protein 2
  • HD-regulating factor 2
  • Synonym symbol(s) PBF, PRF1, HDBP2, PRF-1, Si-1-8-14, DKFZp434K1210, HDBP2
    DNA
    TYPE functioning gene
    STRUCTURE 40.88 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 4807 - 513 - 2009 19018758
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepancreas exocrine   moderately
    Lymphoid/Immunelymph node   highly
     spleen   moderately
     thymus   predominantly
    Reproductivefemale systemplacenta  moderately
     male systemtestis  moderately
    Respiratoryrespiratory tractlarynx  highly
    Urinarykidney   moderately
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two C-terminal four-amino acids motifs conserved to the so-called e-tail of certain T-cell factors)
  • HOMOLOGY
    interspecies homolog to murine Zfp395
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • shift from cytoplasm to nucleus by the treatment with an inhibitor of the nuclear export, leptomycin B, and mutagenesis of the putative nuclear export signals
  • colocalization of ZNF395 and BAG6 in the nucleus might be an important factor for survival of osteosarcoma cells
  • basic FUNCTION
  • might play a role in transcription of PV genes and in E2-mediated repression
  • transcription factors shuttling between nucleus and cytoplasm and binding to the specific GCCGGCG, which is an essential cis-element for HD gene expression in neuronal cells
  • new cellular factor mediating the effects of PI3K/Akt signaling and 14-3-3 on cell growth
  • nuclear-cytoplasmic shuttling factor with the ability to inhibit cell growth
  • acts as a repressor of HPV (human papillomavirus) transcription (repression requires the DNA-binding activity of ZNF395, which we mapped to two C-terminal four-amino acids motifs conserved to the so-called e-tail of certain T-cell factors)
  • ZNF395-mediated repression of transcription involves specific DNA-binding and the recruitment of the SIN3A-HDAC1 complex
  • could induce apoptotic cell death via a caspase-9-independent pathway
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to the specific GCCGGCG
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • binding to the unique promoter DNA sequences of the HD gene
  • directly binds to SAP30 a component of the mSIN3A-HDAC1 complex, via AAs 263-312
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerbone 
    candidate target for immunotherapy in patients with osteosarcoma
    ANIMAL & CELL MODELS