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FLASH GENE

Symbol

ZBTB33

contributors: mct - updated : 17-06-2015

HGNC name	zinc finger and BTB domain containing 33
HGNC id	16682

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Hearing/Equilibrium ear       highly Nervous brain       highly Homo sapiens Urinary bladder       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly Muscular striatum skeletal   highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an N-terminal POZ/BTB domain
	sequence-specific Kaiso binding sites (KBS)
	three C-terminal zinc finger motifs of the C2H2 DNA-binding type

mono polymer

homomer , dimer

HOMOLOGY

interspecies	ortholog to murine Zbtb33
	homolog to xenopus Kaiso

Homologene

FAMILY

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,nucleolus

basic FUNCTION	involved in regulation of transcription, DNA-dependent
	behaving as a methylation-dependent transcriptional repressor
	dual specific DNA-binding protein, functioning as a bimodal regulator of canonical Wnt signaling (Iioka 2009)
	protein acting as a methyl-CpG binding protein by using three zinc-finger domains
	bimodal transcription factor that recognizes methylated CpG dinucleotides or a conserved unmethylated sequence (TNGCAGGA, the Kaiso binding site)
	may possess bimodal activity with regards to its regulation of gene expression (Iioka 2009)
	dual-specificity POZ-ZF transcription factor that regulates gene expression by binding to sequence-specific Kaiso binding sites (KBS) or methyl-CpG dinucleotide pairs
	Cys(2)His(2) zinc finger (ZF) protein that mediates methyl-CpG-dependent and sequence-specific transcriptional repression
	bifunctional Cys(2)His(2) zinc finger protein implicated in tumor-cell proliferation, binds to both methylated CpG (mCpG) sites and a specific nonmethylated DNA motif (TCCTGCNA) and represses transcription by recruiting chromatin remodeling corepression machinery to target genes
	methylated DNA-binding protein and a transcription repressor interacting with the corepressor protein complex NCoR
	is a key regulator of spleen germinal center formation by repressing BCL6 expression in splenocytes

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

intracellular signaling cascade

a component

homodimerized via its POZ domain

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	Zn2+

protein	specific binding partner for the Armadillo catenin and cell adhesion cofactor CTNND1 (Spring 2005) which positively regulate rapsyn expression (Iioka 2009)
	specific binding partner of CTCF (interaction occurs through a C-terminal region of CTCF and the POZ domain of ZBTB33, interaction that negatively regulates CTCF insulator activity)
	interacts with the the N-CoR (nuclear receptor corepressor 1) protein through its POZ/BTB domain (Iioka 2009)
	can regulate LEF1-activity for these effects via modulating HDAC1 and CTNND1-complex formation (Iioka 2009)
	dual-specificity POZ-ZF transcription factor that regulates gene expression by binding to sequence-specific Kaiso binding sites (KBS) or methyl-CpG dinucleotide pairs
	ZNF131 is a ZBTB33-specific binding partner
	when released from CDH1 by WNT3A-stimulated phosphorylation, CTNND1 controls the activity of the ZBTB33 transcriptional factor, enhancing its binding to repressed promoters and relieving its inhibition of the CTNNB-TCF-4 transcriptional complex
	binds to highly active promoters that are marked with high levels of acetylated histones
	stage-specific co-regulators ZBTB33 and SOX10 sequentially interact with TCF7L2 to coordinate the switch at the transitions of differentiation initiation and maturation during oligodendrocyte development

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene	for X-linked mental retardation disorders
Marker	cytoplasmic CTNND1, cytoplasmic ZBTB33, and nuclear MTA2 expression correlated directly with histological type and Masaoka stage and may thus be used as potential biomarkers to predict biological behavior of thymoma
Therapy target

ANIMAL & CELL MODELS