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FLASH GENE
Symbol SERPINC1 contributors: mct/np - updated : 26-03-2010
HGNC name serpin peptidase inhibitor, clade C (antithrombin), member 1
HGNC id 775
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Lymphoid/Immunespleen    
Visualeyeanterior segmentcornea  
cell lineage
cell lines
fluid/secretion plasma
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an heparin binding site
  • a reactive site
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY serpin family
    CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • high molecular weight proteinase inhibitor of blood coagulation, thrombin, F9, F10, F11, F12
  • accelerator of the dissociation of FVIIA complex with tissue factor and preventing its rebinding
  • directly acts on platelets and suppresses ADP-induced platelet granule secretion due to inhibiting HSP27 phosphorylation via MAPK3 and MAPK14 (Doi 2010)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FII
  • FIXa
  • Fxa
  • FXIIa
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AT3
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS