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FLASH GENE

Symbol

SERPINC1

contributors: mct/np - updated : 26-03-2010

HGNC name	serpin peptidase inhibitor, clade C (antithrombin), member 1
HGNC id	775

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	13.53 kb     7 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000488 7 - 1599 52 464 - Picard (2010)

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       highly Lymphoid/Immune spleen         Visual eye anterior segment cornea

cell lineage
cell lines
fluid/secretion	plasma

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an heparin binding site
	a reactive site

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY

serpin family

CATEGORY

enzyme , regulatory

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	high molecular weight proteinase inhibitor of blood coagulation, thrombin, F9, F10, F11, F12
	accelerator of the dissociation of FVIIA complex with tissue factor and preventing its rebinding
	directly acts on platelets and suppresses ADP-induced platelet granule secretion due to inhibiting HSP27 phosphorylation via MAPK3 and MAPK14 (Doi 2010)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	FII
	FIXa
	Fxa
	FXIIa

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

AT3

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS