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FLASH GENE

Symbol

TSPAN4

contributors: - updated : 30-05-2005

HGNC name	tetraspanin 4
HGNC id	11859

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	ubiquitous

constitutive of

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive intestine small intestine     highly   stomach       predominantly Lymphoid/Immune thymus       moderately Reproductive female system uterus cervix   highly   female system ovary     lowly Respiratory lung       lowly Skin/Tegument skin       moderately Visual eye       lowly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		Hydrophobic
STRUCTURE

motifs/domains	four potential transmembrane domaines
	four hydrophobic domains

conjugated

GlycoP

mono polymer

complex

HOMOLOGY

interspecies	ortholog to murine Tm4sf7
	homolog to drosophila Tsp29Fa

Homologene

FAMILY	transmembrane 4 superfamily
	tetraspanin (TM4SF) family

CATEGORY

regulatory , signaling

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

mediating signal transduction events that play a role in the regulation of cell development, activation, growth and motility

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

Forming a complex with integrins

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS