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FLASH GENE
Symbol PIGF contributors: mct - updated : 06-01-2011
HGNC name phosphatidylinositol glycan anchor biosynthesis, class F
HGNC id 8962
DNA
TYPE functioning gene
STRUCTURE 35.84 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1057 24.9 219 - 2000 10781593
7 splicing 1162 23.4 206 - 2000 10781593
alternative exon in the 3'coding region
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
 granular cell
Blood/Hematopoieticerythrocyte
Lymphoid/ImmuneB cell
cell lineage hematopoietic
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six transmembrane segments
    • HOMOLOGY
    Homologene
    FAMILY
  • PIGF family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • glycosyl-phosphatidylinositol (GPI), anchor synthesis, class F
  • involved in transferring the third mannose of the GPI anchor, the first step of the synthesis
  • PIGF is a direct and physiologically relevant transcriptional target of FOXD1
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    glycosylation
    a component
  • GPI7 forms a protein complex with PIGF and is involved in the H7-to-H8 conversion
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PIG-O
  • PIGG is the second partner of PIGF and involved in modification of glycosylphosphatidylinositol
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS