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FLASH GENE
Symbol PIGF contributors: mct - updated : 06-01-2011
HGNC name phosphatidylinositol glycan anchor biosynthesis, class F
HGNC id 8962
Location 2p21      Physical location : 46.808.413 - 46.844.251
Synonym name
  • phosphatidylinositol glycan, class F
  • GPI11 homolog
    • Synonym symbol(s) MGC33136, MGC32646
    DNA
    TYPE functioning gene
    STRUCTURE 35.84 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1057 24.9 219 - 2000 10781593
    7 splicing 1162 23.4 206 - 2000 10781593
    alternative exon in the 3'coding region
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
     granular cell
    Blood/Hematopoieticerythrocyte
    Lymphoid/ImmuneB cell
    cell lineage hematopoietic
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six transmembrane segments
    • HOMOLOGY
    Homologene
    FAMILY
  • PIGF family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • glycosyl-phosphatidylinositol (GPI), anchor synthesis, class F
  • involved in transferring the third mannose of the GPI anchor, the first step of the synthesis
  • PIGF is a direct and physiologically relevant transcriptional target of FOXD1
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    glycosylation
    a component
  • GPI7 forms a protein complex with PIGF and is involved in the H7-to-H8 conversion
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PIG-O
  • PIGG is the second partner of PIGF and involved in modification of glycosylphosphatidylinositol
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS