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FLASH GENE
Symbol SPSB4 contributors: mct - updated : 08-12-2020
HGNC name splA/ryanodine receptor domain and SOCS box containing 4
HGNC id 30630
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a B30.2/SPRY domain
  • a SOCS box domain
    • HOMOLOGY
    interspecies ortholog to murine Ssb4
    homolog to zebrafish nszf-e3261
    intraspecies paralog to SPSB1
    Homologene
    FAMILY SOCS box family of E3 ubiquitin ligases
    CATEGORY signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • involved in intracellular signaling cascade
  • SPSB4 is a previously unidentified ubiquitin ligase regulating EPHB2-dependent cell repulsive responses
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    intracellular signaling cascade
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with MET
  • SPSB1 and SPSB4 bind strongly to both Par-4 and DDX4 peptides
  • SPSB1, SPSB2, SPSB4 can induce the subcellular redistribution of NOS2 from dense regions to diffused expression in a SOCS box-dependent manner
  • SPSB4 down-regulation enhances cell repulsive responses mediated by EPHB2 stimulation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS