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FLASH GENE

Symbol

SPSB4

contributors: mct - updated : 08-12-2020

HGNC name	splA/ryanodine receptor domain and SOCS box containing 4
HGNC id	30630

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	97.26 kb     4 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_080862 3 - 2963 NP_543138 - 273 - 2019 31607207

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       predominantly Reproductive female system ovary     moderately   male system testis     moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a B30.2/SPRY domain
	a SOCS box domain

HOMOLOGY

interspecies	ortholog to murine Ssb4
	homolog to zebrafish nszf-e3261

intraspecies

paralog to SPSB1

Homologene

FAMILY

SOCS box family of E3 ubiquitin ligases

CATEGORY

signaling

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	involved in intracellular signaling cascade
	SPSB4 is a previously unidentified ubiquitin ligase regulating EPHB2-dependent cell repulsive responses

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

intracellular signaling cascade

a component

INTERACTION

DNA

RNA

small molecule

protein	interacts with MET
	SPSB1 and SPSB4 bind strongly to both Par-4 and DDX4 peptides
	SPSB1, SPSB2, SPSB4 can induce the subcellular redistribution of NOS2 from dense regions to diffused expression in a SOCS box-dependent manner
	SPSB4 down-regulation enhances cell repulsive responses mediated by EPHB2 stimulation

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS