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FLASH GENE
Symbol SRCIN1 contributors: mct - updated : 12-01-2018
HGNC name SRC kinase signaling inhibitor 1
HGNC id 29506
PROTEIN
PHYSICAL PROPERTIES Hydrophilic
STRUCTURE
motifs/domains
  • two predicted coiled-coil domains
  • two highly charged regions
  • two proline-rich domains with multiple PPXY and PXXP motifs
  • conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to murine P140
    ortholog to rattus SNIP
    Homologene
    FAMILY
  • p140Cap family
  • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • delaying the onset of cell spreading in the early stages of cell adhesion to fibronectin
  • involved in calcium- dependent exocytosis from PC12 cells
  • playing a role in controling actin cytoskeleton organization in response to adhesive and growth factor signaling
  • involved in regulation of neurosecretion, perhaps via its interaction with SNAP-25 and the cytoskeleton
  • is an adaptor protein considered to play pivotal roles in cell adhesion, growth and SRC tyrosine kinase-related signaling in non-neuronal cells
  • is likely involved in neurotransmitter release, synapse formation/maintenance, and signaling
  • Src-binding protein that regulates Src activation through C-terminal Src kinase (Csk)
  • mechanistically behaves as a tumour suppressor that inhibits signalling pathways leading to aggressive phenotypes
  • regulates tumor properties in terms of cell motility and growth
  • suppresses the invasive properties of highly metastatic breast carcinoma cells by inhibiting cortactin-dependent cell motility
  • played a tumor suppressor role in the development of lung cancer and breast cancer
  • acted as a tumor suppressor gene in the development of osteosarcoma
  • adaptor protein SRCIN1 is a novel SRC-binding protein that regulates SRC activation through C-terminal SRC kinase (Csk)
  • SRCIN1 contributes to colorectal carcinogenesis, invasion and metastasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS exocytosis transport
    PATHWAY
    metabolism
    signaling
    a component
  • tyrosine-phosphorylated
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • suppresses the invasive properties of highly metastatic breast carcinoma cells by inhibiting cortactin-dependent cell motility
  • SNAP25 likely allows the organization of the molecular apparatus needed for spine formation by recruiting and stabilizing SRCIN1
  • regulates memory and synaptic plasticity through SRC-mediated and CIT-N-mediated actin reorganization
  • SRCIN1, a regulator of cytoskeleton reorganization, is a downstream effector of SH3GL2 and disruption of their interaction impairs spine formation and maturation
  • presynaptic CTNNB1 expression enhanced release probability of glutamatergic synapses, and newly identified CTNNB1-interacting protein SRCIN1 is required in the presynaptic locus for mediating these effects
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS