Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

GRHL3

contributors: mct - updated : 29-04-2019

HGNC name	grainyhead-like 3 (Drosophila)
HGNC id	25839

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

VWS3

Susceptibility

to nonsyndromic cleft lip with/without cleft palate

Variant & Polymorphism other	dominant GRHL3 mutations are more likely to cause nonsyndromic than syndromic CPO

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive breast new therapeutic strategies with the aim to conserve GRHL3 expression in the vasculature

ANIMAL & CELL MODELS

	Grhl3-/- embryos have only oral epithelial adhesions because of the loss of periderm
	mice lacking Grhl3 have an exacerbated epidermal damage response, greater sensitivity to disease induction, delayed resolution of epidermal lesions