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FLASH GENE
Symbol GRHL3 contributors: mct - updated : 29-04-2019
HGNC name grainyhead-like 3 (Drosophila)
HGNC id 25839
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , heteromer , dimer
HOMOLOGY
Homologene
FAMILY grainyhead family of transcription factors
CATEGORY transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus,nucleoplasm
basic FUNCTION
  • may function as a transcription factor during development
  • regulates formation of the epidermal leading edge during eyelid closure
  • GRHL3 and LMO4 play coordinate roles in epidermal migration
  • may play important roles in mammalian development
  • cooperative roles of the GRHL genes in epidermal development
  • required for endothelial cell migration
  • nitric oxide dependent migration is completely dependent on GRHL3 expression, in breast cancer cells
  • IRF6 and GRHL3 are essential for the presence of a functional oral periderm and that failure of this process contributes to VWS
  • is essential during epidermal development, is dispensable for adult skin homeostasis, but required for barrier repair after adult epidermal injury
  • contributions of GRHL3, SSTR2 and SSTR4 receptors in olfactory processing
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    TFAP2A-IRF6-GRHL3 genetic pathway is shared by two embryologically distinct morphogenetic events that previously were considered independent during mammalian development
    a component homodimers and heterodimers with GRHL1 and GRHL2
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LMO4 serves as a functional partner of GRHL3
  • GRHL3/GET1 recruits the ubiquitously expressed Trithorax complex to a subset of differentiation genes
  • major role for GRHL3 in the induction of migration and invasion by the downregulation of CDH1 in cancer cells
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) VWS3
    Susceptibility to nonsyndromic cleft lip with/without cleft palate
    Variant & Polymorphism other dominant GRHL3 mutations are more likely to cause nonsyndromic than syndromic CPO
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    new therapeutic strategies with the aim to conserve GRHL3 expression in the vasculature
    ANIMAL & CELL MODELS
  • Grhl3-/- embryos have only oral epithelial adhesions because of the loss of periderm
  • mice lacking Grhl3 have an exacerbated epidermal damage response, greater sensitivity to disease induction, delayed resolution of epidermal lesions