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FLASH GENE
Symbol CHSY3 contributors: mct/npt - updated : 22-04-2009
HGNC name chondroitin sulfate synthase 3
HGNC id 24293
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a beta 3-glycosyltransferase motif
  • a beta 4-glycosyltransferase motif similar to that found in CSS1
    • HOMOLOGY
    intraspecies homolog to CHSY1
    Homologene
    FAMILY
  • chondroitin N- acetylgalactosaminyltransferase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text type II membrane protein
    basic FUNCTION
  • glycosyltransferase having both glucuronyltransferase and N-acetylgalactosaminyltransferase activities
  • possess GalNAcT-II (N-acetylgalactosaminyltransferase-II) and GlcAT-II (glucuronyltransferase-II) activities responsible for the elongation of CS (chondroitin sulfate) chains but cannot polymerize chondroitin chains by themselves (Izumikawa 2007)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interactions between any two of CHSY1, CHSY3 and CHPF (Izumikawa 2007)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS