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FLASH GENE

Symbol

CHSY3

contributors: mct/npt - updated : 22-04-2009

HGNC name	chondroitin sulfate synthase 3
HGNC id	24293

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 3 - 3523 100.3 882 - Izumikawa (2007)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Respiratory respiratory tract larynx     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a beta 3-glycosyltransferase motif
	a beta 4-glycosyltransferase motif similar to that found in CSS1

HOMOLOGY

intraspecies

homolog to CHSY1

Homologene

FAMILY

chondroitin N- acetylgalactosaminyltransferase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
text	type II membrane protein

basic FUNCTION	glycosyltransferase having both glucuronyltransferase and N-acetylgalactosaminyltransferase activities
	possess GalNAcT-II (N-acetylgalactosaminyltransferase-II) and GlcAT-II (glucuronyltransferase-II) activities responsible for the elongation of CS (chondroitin sulfate) chains but cannot polymerize chondroitin chains by themselves (Izumikawa 2007)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interactions between any two of CHSY1, CHSY3 and CHPF (Izumikawa 2007)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS