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FLASH GENE
Symbol CHSY3 contributors: mct/npt - updated : 22-04-2009
HGNC name chondroitin sulfate synthase 3
HGNC id 24293
DNA
TYPE functioning gene
STRUCTURE 281.80 kb     3 Exon(s)
regulatory sequence Binding site
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 3523 100.3 882 - Izumikawa (2007)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Respiratoryrespiratory tractlarynx  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a beta 3-glycosyltransferase motif
  • a beta 4-glycosyltransferase motif similar to that found in CSS1
    • HOMOLOGY
    intraspecies homolog to CHSY1
    Homologene
    FAMILY
  • chondroitin N- acetylgalactosaminyltransferase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text type II membrane protein
    basic FUNCTION
  • glycosyltransferase having both glucuronyltransferase and N-acetylgalactosaminyltransferase activities
  • possess GalNAcT-II (N-acetylgalactosaminyltransferase-II) and GlcAT-II (glucuronyltransferase-II) activities responsible for the elongation of CS (chondroitin sulfate) chains but cannot polymerize chondroitin chains by themselves (Izumikawa 2007)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interactions between any two of CHSY1, CHSY3 and CHPF (Izumikawa 2007)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS