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FLASH GENE

Symbol

NCAM2

contributors: npt/ - updated : 03-10-2005

HGNC name	neural cell adhesion molecule 2
HGNC id	7657

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	21q21.1      Physical location : 22.370.632 - 22.911.214
Synonym name	neural cell adhesion molecule 2 precursor
Synonym symbol(s)	NCAM21, MGC51008

DNA

TYPE	functioning gene
STRUCTURE	540.58 kb     18 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map	cen - D21S18 - D21S1256 - D21S1914 - NCAM2 - D21S265 - D21S1435 - D21S1442 - qter
Authors	Paoloni-Giacobino (97)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 18 - 3699 isoform1 91 837 - Paoloni-Giacobino (1997)

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	five immunoglobulin-like (Ig) extracellular domains
	two fibronectin type III-like domains

HOMOLOGY

Homologene

FAMILY

immunoglobulin superfamily

CATEGORY

adhesion

SUBCELLULAR LOCALIZATION

basic FUNCTION

could have a role in the molecular mechanism of homophilic binding (Rasmussen 2008)

CELLULAR PROCESS

cell communication

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS