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FLASH GENE

Symbol

LSS

contributors: mct - updated : 26-10-2018

HGNC name	lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
HGNC id	6708

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

ARCC8 , HTS6

Susceptibility

to mild essential hypertension

Variant & Polymorphism other	rs2254524 polymorphisms influence both the salt sensitivity of blood pressure (BP) and changes in circulating endogenous ouabain (EO) in response to a low salt diet

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed miscelleaneous dermatology   may facilitate the development of novel therapies for hair loss

ANIMAL & CELL MODELS

plasma cholesterol-lowering and transient liver dysfunction in mice lacking squalene synthase in the liver