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FLASH GENE
Symbol TXNDC12 contributors: mct - updated : 08-06-2013
HGNC name thioredoxin domain containing 12 (endoplasmic reticulum)
HGNC id 24626
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  moderately
 stomach   highly
Lymphoid/Immunethymus   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a putative N-terminal signal sequence
  • a thioredoxin-like motif
  • C-terminal ER retention motif (EDEL)
    • HOMOLOGY
    interspecies homolog to C. elegans 2M531
    intraspecies homolog to ERP29, AGR2
    Homologene
    FAMILY thioredoxin superfamily
    CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    text secreted out of cell through trans-Golgi network (TGN)
    basic FUNCTION
  • having Trx enzymatic activity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS