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FLASH GENE
Symbol TXNDC12 contributors: mct - updated : 08-06-2013
HGNC name thioredoxin domain containing 12 (endoplasmic reticulum)
HGNC id 24626
Location 1p32.3      Physical location : 52.485.806 - 52.521.047
Synonym name
  • endoplasmic reticulum thioredoxin superfamily member, 18 kDa
  • anterior gradient homolog 1 (Xenopus laevis)
  • thioredoxin-like protein p19
    • Synonym symbol(s) ERP18, ERP19, TLP19, AGR1
    EC.number 1.8.4.2
    DNA
    TYPE functioning gene
    STRUCTURE 35.00 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  moderately
     stomach   highly
    Lymphoid/Immunethymus   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a putative N-terminal signal sequence
  • a thioredoxin-like motif
  • C-terminal ER retention motif (EDEL)
    • HOMOLOGY
    interspecies homolog to C. elegans 2M531
    intraspecies homolog to ERP29, AGR2
    Homologene
    FAMILY thioredoxin superfamily
    CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    text secreted out of cell through trans-Golgi network (TGN)
    basic FUNCTION
  • having Trx enzymatic activity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS