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FLASH GENE
Symbol PRSS27 contributors: - updated : 08-06-2006
HGNC name protease, serine 27
HGNC id 15475
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 22 aa typical signal peptide
  • a 12-residue activation peptide cleaved by tryptic hydrolysis
  • a 256-amino acid catalytic domain (peptidase S1 domain)
  • two putative N-glycosylation sites
    • secondary structure peptidase S1 domain
    conjugated GlycoP
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to rattus Mpn (75.8pc)
    homolog to murine Prss27 (77.5pc)
    Homologene
    FAMILY
  • peptidase S1 family
    • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    text
  • secreted protein
    • basic FUNCTION
  • tryptic serine protease of the pancreas that cleaves peptides after an arginine residue
  • acting as a serine-type endopeptidase
    • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • N-glycosylated
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by benzamidine and leupeptin
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS