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FLASH GENE

Symbol

PRSS27

contributors: - updated : 08-06-2006

HGNC name	protease, serine 27
HGNC id	15475

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly   pharynx       specific   stomach         Reproductive female system uterus cervix   moderately Skin/Tegument skin

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a 22 aa typical signal peptide
	a 12-residue activation peptide cleaved by tryptic hydrolysis
	a 256-amino acid catalytic domain (peptidase S1 domain)
	two putative N-glycosylation sites

secondary structure

peptidase S1 domain

conjugated

GlycoP

isoforms

Precursor

HOMOLOGY

interspecies	homolog to rattus Mpn (75.8pc)
	homolog to murine Prss27 (77.5pc)

Homologene

FAMILY

peptidase S1 family

CATEGORY

enzyme , regulatory

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,mitochondria
text	secreted protein

basic FUNCTION	tryptic serine protease of the pancreas that cleaves peptides after an arginine residue
	acting as a serine-type endopeptidase

CELLULAR PROCESS

protein, degradation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

N-glycosylated

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

inhibited by

benzamidine and leupeptin

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS