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FLASH GENE
Symbol PRSS27 contributors: - updated : 08-06-2006
HGNC name protease, serine 27
HGNC id 15475
Location 16p13.3      Physical location : 2.762.423 - 2.770.552
Synonym name
  • marapsin
  • pancreasin
  • channel-activating protease 2
    • Synonym symbol(s) CAPH2, MPN
    EC.number 3.4.21.-
    DNA
    TYPE functioning gene
    STRUCTURE 8.00 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    regionally located . centromeric to the tryptase genes (e.g., TPSB1) and telomeric to the testisin gene (PRSS21)
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     pharynx   specific
     stomach    
    Reproductivefemale systemuteruscervix moderately
    Skin/Tegumentskin    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 22 aa typical signal peptide
  • a 12-residue activation peptide cleaved by tryptic hydrolysis
  • a 256-amino acid catalytic domain (peptidase S1 domain)
  • two putative N-glycosylation sites
    • secondary structure peptidase S1 domain
    conjugated GlycoP
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to rattus Mpn (75.8pc)
    homolog to murine Prss27 (77.5pc)
    Homologene
    FAMILY
  • peptidase S1 family
    • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    text
  • secreted protein
    • basic FUNCTION
  • tryptic serine protease of the pancreas that cleaves peptides after an arginine residue
  • acting as a serine-type endopeptidase
    • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • N-glycosylated
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by benzamidine and leupeptin
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS