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FLASH GENE
Symbol VSNL1 contributors: mct - updated : 26-03-2011
HGNC name visinin-like 1
HGNC id 12722
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • and an N-terminal myristoylation consensus sequence
  • four EF-hand calcium binding protein (EF1, EF2, EF3, and EF4), with a sequence CPXG in the first EF-hand that eliminates its capacity to bind Ca2+
    • HOMOLOGY
    interspecies homolog to rattus Rnvp1
    Homologene
    FAMILY
  • recoverin family, neuronal EF-hand calcium-sensor protein family
  • neuronal calcium sensor family of Ca2+-myristoyl switch proteins
    • CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • calcium sensor, likely involved in signal transduction
  • modulating intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase
  • playing a critical role in regulating cell adhesion and migration by downregulation of fibronectin receptor expression
  • regulates the cell surface localization of natriuretic peptide receptor B (NPR2)
  • regulates several neuronal signaling pathways implicated in synaptic plasticity, such as cyclic nucleotide cascades and nicotinergic signaling
  • important Ca2+ sensor for controlling neuronal excitability by modulating nicotinergic neurotransmission important for synaptic plasticity and disease processes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text CNS development
    PATHWAY
    metabolism
    signaling sensory transduction/vision
    phosphotransduction
    a component
  • forms a dimer in solution independent of Ca2+ and myristoylation
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • myristoyl group
  • calcium Ca2+
  • binds functionally to Mg2+ at EF3 and binds cooperatively to Ca2+ at EF2 and EF3
    • protein
  • regulating the inhibition of Ca2+ dependent rhodopsin phosphorylation
  • binding NTRK2 mRNA
  • interacting with P2X2 receptors and displaying enhanced interactions in an activation- and calcium-dependent manner owing to exposure of its binding segment in P2X2 receptors
  • NRF1 could be a regulatory factor for VSNL1 gene expression and for other visinin-like subfamily members including HPCAL4, HPCAL1, HPCA, and NCALD
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS