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FLASH GENE
Symbol VSNL1 contributors: mct - updated : 26-03-2011
HGNC name visinin-like 1
HGNC id 12722
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart     Homo sapiens
Nervousbrainhindbraincerebellum  
 brain   highly Homo sapiens
 brainlimbic systemhippocampus highly Homo sapiens
Respiratoryrespiratory tractlarynx  highly
Urinarykidney    
Visualeyeretina   
cells
SystemCellPubmedSpeciesStageRna symbol
Muscularmyocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • and an N-terminal myristoylation consensus sequence
  • four EF-hand calcium binding protein (EF1, EF2, EF3, and EF4), with a sequence CPXG in the first EF-hand that eliminates its capacity to bind Ca2+
    • HOMOLOGY
    interspecies homolog to rattus Rnvp1
    Homologene
    FAMILY
  • recoverin family, neuronal EF-hand calcium-sensor protein family
  • neuronal calcium sensor family of Ca2+-myristoyl switch proteins
    • CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • calcium sensor, likely involved in signal transduction
  • modulating intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase
  • playing a critical role in regulating cell adhesion and migration by downregulation of fibronectin receptor expression
  • regulates the cell surface localization of natriuretic peptide receptor B (NPR2)
  • regulates several neuronal signaling pathways implicated in synaptic plasticity, such as cyclic nucleotide cascades and nicotinergic signaling
  • important Ca2+ sensor for controlling neuronal excitability by modulating nicotinergic neurotransmission important for synaptic plasticity and disease processes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text CNS development
    PATHWAY
    metabolism
    signaling sensory transduction/vision
    phosphotransduction
    a component
  • forms a dimer in solution independent of Ca2+ and myristoylation
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • myristoyl group
  • calcium Ca2+
  • binds functionally to Mg2+ at EF3 and binds cooperatively to Ca2+ at EF2 and EF3
    • protein
  • regulating the inhibition of Ca2+ dependent rhodopsin phosphorylation
  • binding NTRK2 mRNA
  • interacting with P2X2 receptors and displaying enhanced interactions in an activation- and calcium-dependent manner owing to exposure of its binding segment in P2X2 receptors
  • NRF1 could be a regulatory factor for VSNL1 gene expression and for other visinin-like subfamily members including HPCAL4, HPCAL1, HPCA, and NCALD
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS