Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol OTUD6B contributors: mct - updated : 10-05-2017
HGNC name OTU domain containing 6B
HGNC id 24281
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
an OTU domain
HOMOLOGY
interspecies ortholog to murine Otud6b
Homologene
FAMILY ovarian tumor domain (OTU)-containing subfamily of deubiquitinating enzymes
CATEGORY DNA associated
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • potential role for OTUD6B in proteasome function
  • potential role of OTUD6B in removing ubiquitin and/or ubiquitin chains from protein substrates, and it may regulate the ubiquitin-proteasome system
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MRSDF
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    down-regulation of OTUD6B expression after prolonged cytokine stimulation may be required for cell proliferation in B lymphocytes
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS