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FLASH GENE
Symbol OTUD6B contributors: mct - updated : 10-05-2017
HGNC name OTU domain containing 6B
HGNC id 24281
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  moderately
Lymphoid/Immunelymph node   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
an OTU domain
HOMOLOGY
interspecies ortholog to murine Otud6b
Homologene
FAMILY ovarian tumor domain (OTU)-containing subfamily of deubiquitinating enzymes
CATEGORY DNA associated
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • potential role for OTUD6B in proteasome function
  • potential role of OTUD6B in removing ubiquitin and/or ubiquitin chains from protein substrates, and it may regulate the ubiquitin-proteasome system
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MRSDF
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    down-regulation of OTUD6B expression after prolonged cytokine stimulation may be required for cell proliferation in B lymphocytes
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS