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FLASH GENE
Symbol DNM3 contributors: mct - updated : 04-11-2014
HGNC name dynamin 3
HGNC id 29125
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a pleckstrin homology (PH) domain that binds phosphoinositides and this interaction appears to be crucial for its function (Bethoney 2009)
    • HOMOLOGY
    Homologene
    FAMILY
  • dynamin family
  • super-family of large GTPase proteins
    • CATEGORY adhesion , enzyme , regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    text
  • is present in the terminals of photoreceptors and dendrites of second-order neurons but is most pronounced in the inner plexiform layer where second-order neurons relay signals from photoreceptors
    • basic FUNCTION
  • may be involved in vesicular trafficking processes, in
    • particular endocytosis
  • DNM1, DNM2, DNM3, decode action potential firing for synaptic vesicle recycling
  • GTPase protein that polymerise during their biological activity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL1QM
    Susceptibility
    Variant & Polymorphism
    Candidate gene for the cognitive disability in del 1q25q25 microdeletion syndrome
    Marker
    Therapy target
    ANIMAL & CELL MODELS