Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MECR contributors: mct - updated : 18-01-2017
HGNC name mitochondrial trans-2-enoyl-CoA reductase
HGNC id 19691
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
interspecies ortholog to murine Nrbf1
ortholog to rattus Nrbf1
homolog to C. elegans ETR1
Homologene
FAMILY
  • zinc-containing alcohol dehydrogenase family
  • quinone oxidoreductase subfamily
    • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    basic FUNCTION
  • acting as an alcohol dehydrogenase
  • catalyzing the reduction of trans-2-enoyl-CoA to acyl-CoA with chain length from C6 to C16 in an NADPH-dependent manner with preference to medium chain length substrate
  • catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters, generating saturated acyl-groups
  • may have a role in the mitochondrial synthesis of fatty acids
  • role of MECR in peroxisome-proliferator-activator-receptor (PPAR)-dependent signaling
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
  • fatty acid biosynthesis
  • lipid synthesis
  • involved in mitochondrial fatty acid synthesis (mtFASII), that may be involved in the regulation of bioactive lipid levels pathway
    • a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor, nucleotide,
  • Zn2+
  • NADP
    • protein
  • binding protein of the nuclear hormone receptor peroxisome proliferator-activated receptor alpha (PPARA), but the presence of a cytosolic or nuclear isoform of MECR is necessary for functional interaction between MECR and PPARA
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DYTOABG
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Mecr transgenic mice developed cardiac abnormalities (pMID: 1944339)