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FLASH GENE
Symbol MTTP contributors: mct - updated : 12-03-2016
HGNC name microsomal triglyceride transfer protein (large polypeptide, 88kDa)
HGNC id 7467
ASSOCIATED DISORDERS
corresponding disease(s) ABLP
related resource MITOP database
Susceptibility
  • for higher levels of triglycerides, and LDL cholesterol APOB
  • susceptibility to osteoporosis
  • to type 2 diabetes
  • Variant & Polymorphism SNP , other
  • polymorphism 493TT increasing the BMD in premenopausal women
  • variant(rare alleles) associated with higher levels of triglycerides and APOB
  • rare allele I128T polymorphism may be protective against impaired glucose tolerance, type 2 diabetes and other parameters of the metabolic syndrome
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    digestiveliver 
    critical target for the prevention and treatment of nonalcoholic steatohepatitis
    ANIMAL & CELL MODELS