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FLASH GENE
Symbol MTTP contributors: mct - updated : 12-03-2016
HGNC name microsomal triglyceride transfer protein (large polypeptide, 88kDa)
HGNC id 7467
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
large 97kDa subunit
mono polymer homomer , dimer
HOMOLOGY
Homologene
FAMILY
CATEGORY transport carrier
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,lumen
intracellular,cytoplasm,organelle,endoplasmic reticulum
intracellular,cytoplasm,organelle,Golgi
intracellular,cytoplasm,cytosolic,microsome
basic FUNCTION
  • microsomal triglyceride transfer protein, playing a central role in lipoprotein and chylomicrons assembly
  • catalyzing the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces
  • required for the secretion of plasma lipoproteins that contain APOB
  • regulating CD1D function in the endoplasmic reticulum
  • required for the assembly and secretion of apolipoprotein B (apoB)-containing lipoproteins from the intestine and liver
  • is a unique regulator of human metabolic and immune pathways
  • its expression requires hepatic nuclear factor HNF4A transcription factor
  • CLOCK, MTTP, and NOCT are involved in the circadian regulation of intestinal lipid absorption
  • is a cellular lipid transfer protein that differs from those present in the blood
  • may likely play a role in the control of walking, voluntary movement, and speaking
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component dimerizing with disulfide isomerase (PDI), involved in the assembly and secretion of APOB-containing lipoproteins
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NR2F1 and ERN2 suppress MTTP expression and lipoprotein assembly in undifferentiated intestinal epithelial cell
  • regulate the CD1 family of lipid antigen-presenting molecules
  • NR2F1 suppresses synergistic activation of the MTTP promoter by HNF4A/HNF1A by binding to a direct repeat 1 (DR1) element
  • APOA4 modulates diurnal changes in lipid absorption by regulating forkhead transcription factors and MTTP and inhibition of APOA4 expression might reduce plasma lipids
  • MTTP prevents APOB degradation and favors its assembly into lipoproteins
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ABLP
    related resource MITOP database
    Susceptibility
  • for higher levels of triglycerides, and LDL cholesterol APOB
  • susceptibility to osteoporosis
  • to type 2 diabetes
    • Variant & Polymorphism SNP , other
  • polymorphism 493TT increasing the BMD in premenopausal women
  • variant(rare alleles) associated with higher levels of triglycerides and APOB
  • rare allele I128T polymorphism may be protective against impaired glucose tolerance, type 2 diabetes and other parameters of the metabolic syndrome
    • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    digestiveliver 
    critical target for the prevention and treatment of nonalcoholic steatohepatitis
    ANIMAL & CELL MODELS