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FLASH GENE
Symbol MTTP contributors: mct - updated : 12-03-2016
HGNC name microsomal triglyceride transfer protein (large polypeptide, 88kDa)
HGNC id 7467
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
19 - 4093 - 894 - -
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus    
 intestinesmall intestine   
 liver    
Reproductivemale systemtestis   
Urinarykidney    
Visualeyeretina   
cells
SystemCellPubmedSpeciesStageRna symbol
Digestivehepatocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
large 97kDa subunit
mono polymer homomer , dimer
HOMOLOGY
Homologene
FAMILY
CATEGORY transport carrier
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,lumen
intracellular,cytoplasm,organelle,endoplasmic reticulum
intracellular,cytoplasm,organelle,Golgi
intracellular,cytoplasm,cytosolic,microsome
basic FUNCTION
  • microsomal triglyceride transfer protein, playing a central role in lipoprotein and chylomicrons assembly
  • catalyzing the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces
  • required for the secretion of plasma lipoproteins that contain APOB
  • regulating CD1D function in the endoplasmic reticulum
  • required for the assembly and secretion of apolipoprotein B (apoB)-containing lipoproteins from the intestine and liver
  • is a unique regulator of human metabolic and immune pathways
  • its expression requires hepatic nuclear factor HNF4A transcription factor
  • CLOCK, MTTP, and NOCT are involved in the circadian regulation of intestinal lipid absorption
  • is a cellular lipid transfer protein that differs from those present in the blood
  • may likely play a role in the control of walking, voluntary movement, and speaking
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component dimerizing with disulfide isomerase (PDI), involved in the assembly and secretion of APOB-containing lipoproteins
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NR2F1 and ERN2 suppress MTTP expression and lipoprotein assembly in undifferentiated intestinal epithelial cell
  • regulate the CD1 family of lipid antigen-presenting molecules
  • NR2F1 suppresses synergistic activation of the MTTP promoter by HNF4A/HNF1A by binding to a direct repeat 1 (DR1) element
  • APOA4 modulates diurnal changes in lipid absorption by regulating forkhead transcription factors and MTTP and inhibition of APOA4 expression might reduce plasma lipids
  • MTTP prevents APOB degradation and favors its assembly into lipoproteins
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ABLP
    related resource MITOP database
    Susceptibility
  • for higher levels of triglycerides, and LDL cholesterol APOB
  • susceptibility to osteoporosis
  • to type 2 diabetes
  • Variant & Polymorphism SNP , other
  • polymorphism 493TT increasing the BMD in premenopausal women
  • variant(rare alleles) associated with higher levels of triglycerides and APOB
  • rare allele I128T polymorphism may be protective against impaired glucose tolerance, type 2 diabetes and other parameters of the metabolic syndrome
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    digestiveliver 
    critical target for the prevention and treatment of nonalcoholic steatohepatitis
    ANIMAL & CELL MODELS